Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization
Figure 6
Correlation of pro-inflammatory T cell cytokine response to the bacterial burden (CFU per granuloma) in each of the individual granulomas.
Significant inverse correlation was observed between frequencies of TNF (A) and T-1/T-17 (B) producing T cells and bacterial burden. CFU per granuloma value of zero were transformed to “1” and included in this analysis. Each symbol represents a granuloma. Line indicates the slope. The clinical status of an animal is represented by the color of the granuloma. Animals with active disease are in red, latent infection in blue and those with ∼11 weeks of infection are in green.