Preferential Use of Central Metabolism In Vivo Reveals a Nutritional Basis for Polymicrobial Infection
Figure 6
Polymicrobial urinary tract infection with E. coli and P. mirabilis enhances persistent bacterial colonization.
Colonization levels following independent infections of female CBA/J mice with (A) UPEC strain CFT073 or (B) P. mirabilis HI4320. Colonization levels at (C) 48 hpi and (D) 7 dpi following polymicrobial infection of female CBA/J mice inoculated with a mixture of CFT073 and HI4320. The CFU/g of tissue for UPEC (circles) and P. mirabilis (squares) from bladders (closed symbols) and kidneys (open symbols) from individual animals at 48 hpi for (C) or 7 dpi for (A, B, D). Bars indicate the median values.