Selective Susceptibility of Human Skin Antigen Presenting Cells to Productive Dengue Virus Infection
Figure 5
Heatmap of differentially regulated genes in DENV infected skin DC subsets.
(A) Nanostring gene expression analysis of sorted human skin DC subsets exposed to DENV-2 (MOI 2) for 24 h. (B) Summary data of three genes that were significantly elevated by DENV exposure in CD14+, CD1c+ DCs and LCs cultures. Each dot represents one donor. (C) Protein levels of IFN-β and CCL5 produced by dermal cells and by LCs stimulated with UV-inactivated and LIVE DENV-2 for 48 h and measured by ELISA, each dot represents one donor.