Crystal Structure of Calcium Binding Protein-5 from Entamoeba histolytica and Its Involvement in Initiation of Phagocytosis of Human Erythrocytes
Figure 2
A) Alignment of the Ca2+ bound EF-hand motif of EhCaBP5 (blue) with that of Potato CaM (pink, pdb code 1RFJ). The r.m.s.d. of alignment is 2.38 Å. The interhelical angles of the EF-hand motifs of EhCaBP5 and CaM are 64.3 Å and 89.3 Å, respectively, indicative in turn of the closed and open conformations. (B) Alignment of the Ca2+ bound EF-hand motif of EhCaBP5 (blue) with that of squid ELC (yellow, pdb code 1QVI), physarum ELC (green, pdb code 2BLO), and a mutant CaM (pink, pdb code 1Y6W). The rmsd's of the alignments are1.6 Å, 1.3 Å and 1.08 Å, respectively.