Aminoterminal Amphipathic α-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production
Figure 9
Dual membrane topology of HCV NS4B.
The N-terminal part of NS4B assumes a dual membrane topology. Cartoons illustrating the (A) cytosolic and the (B) luminal endoplasmic reticulum (ER) membrane topology of the N-terminal part of NS4B are shown. TMs, predicted transmembrane segments.