ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence
Figure 7
A sub-set of SrbA ChIP Target Genes are co-regulated by SrbB.
The RNA-seq data for annotated genes corresponding to SrbA ChIP-seq peaks are shown as ratios of 30 and 120-minute wild-type hypoxia vs. wild-type normoxia, and gene deletion strains are shown as the deletion strain vs. the equivalent wild type hypoxia time point. Genes discussed and/or examined in detail in this manuscript are noted with asterisks. MeV analysis was performed using hierarchical clustering. Optimized gene and leaf ordering groups the wild type 30- and 120-minute hypoxic conditions together, with the 30-minute ΔsrbA sample more similar to wild type for the SrbA targets, using Pearson correlation with complete linkage clustering.