Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer
Figure 5
Impairment of autophagy decreases trimethylation at H3K4 in human monocytes.
ChIP analysis of the enrichment of H3K4me3 at the promoter of (A) TNF-α and (B) IL-6 in human monocytes isolated from volunteers carrying the major variant (GG) or minor variant (CC) alleles for ATG2B after training with BCG. ChIP analysis of the enrichment of H3K4me3 at the promoter of (C) TNF-α and (D) IL-6 in human monocytes trained with BCG in the presence or absence of 3MA *p<0.05, **p<0.01.