Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health
Figure 5
An overview of gene expression profiles in IAPV infected adults and brood.
(A) Venn graph compares regulated genes between adult and brood. The intersecting circles indicate overlapping genes between adult and brood. Of 4615 genes with altered expression in IAPV-positive adult and 1350 genes with altered expression in IAPV-positive brood, the number of overlapping genes between adults and brood was 336. (B) A heat map illustrates differential expression profiles of up- and down- regulated genes for adults and brood. The number of genes with altered expression was significantly higher in IAPV infected adult than in IAPV infected brood. The relative levels of gene expression are depicted using a color scale where blue indicates the lowest and red indicates the highest level of expression. Significantly enriched Gene Ontology (GO) terms of up- and down regulated gene clusters inducted by IAPV infection (ρ≤0.05) appear on the right side of the heat map.