Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine
Figure 5
Histopathology scores of C57BL/6 mice after i.g. inoculation with Salmonella.
All groups received 107 cfu except conventional mice (D), which received 109 cfu. A) Germ-free (GF) mice 24 hours post-infection with wild-type MA43 and fraB1::kan mutant MA59; B) GF mice 24 hours post-infection with SPI1− SPI2− Salmonella (fra+ MA4301 vs fraB1::cam mutant MA5900); C) GF mice 24 hours post-infection with ttrA− Salmonella (fra+ MA4310 vs fraB1::kan mutant MA5910); D) Conventional mice 24 hours post-infection with wild-type MA43 and fraB1::kan mutant MA59. E) Strep-treated (ST) mice 4 days post-infection with wild-type IR715 and fraB1::kan mutant MA59; F) ST mice 4 days post-infection with SPI1− SPI2− Salmonella (fra+ MA4301 and fraB1::cam mutant MA5900; G) ST mice 4 days post-infection with ttrA− Salmonella (fra+ MA4310 vs fraB1::kan mutant MA5910). Error bars represent mean+SD. Statistical significance between select groups was determined using a Mann-Whitney test. * = P value<0.05, ** = P value<0.01.