An Invertebrate Warburg Effect: A Shrimp Virus Achieves Successful Replication by Altering the Host Metabolome via the PI3K-Akt-mTOR Pathway
Figure 6
Schematic representation of the WSSV-induced Warburg effect and the involvement of the PI3K-Akt-mTOR pathway at the viral genome replication stage (12 hpi) of the first WSSV replication cycle.
For the proteins investigated in this study, red indicates a positive involvement and gray indicates a partial involvement. Blue indicates important upregulated proteins and intermediates from previous studies: Glucose transporter (GLU1) is from Huang et al. [25], and G6PDH is from Chen et al. [9]. Elevated metabolic pathways are shown in pink. Pathway inhibitors are indicated in black boxes. Dashed lines indicate inferred regulatory mechanisms that were not investigated in the present study.