Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo
Figure 5
A3G but not A3A is packaged into M-MLV and inhibits reverse transcription.
A) and B) Virions were isolated from the spleens of A3G (A), A3A (B), wild type and KO mice and EnRT assays were performed. Shown is the average of 3 independent experiments using different virus preparations; error bars show standard deviation. C) Western blot analysis of M-MLV virions from the transgenic mice, using anti-myc antisera (top panel). The blots were stripped and reprobed with anti-MLV antisera (bottom panel). Abbreviations: CA, capsid; +, extracts from 293T cells transfected with the A3A or A3G transgenes.