IL-1α and Complement Cooperate in Triggering Local Neutrophilic Inflammation in Response to Adenovirus and Eliminating Virus-Containing Cells
Figure 2
Kinetics of Ly-6G+7/4+ leukocyte recruitment and retention in the spleen in response to intravascular administration of adenovirus.
Accumulation of Ly-6G+7/4+ cells in the spleen over time after injection of mice with escalating doses of Ad, shown as virus particles per mouse. Data obtained from three independent experiments are shown. Mock mice were injected with phosphate-buffered saline (PBS) only. Splenocytes were harvested, stained with antibodies for Ly-6G and 7/4 cellular markers and analyzed by flow cytometry. N = 4. * - P<0.05; ** - P<0.01. Error bars represent standard deviation of a mean.