Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission
Figure 5
Antiretroviral inhibitors and combinations that are effective against HIV-1 cell-to-cell transmission are effective against high viral MOI.
(A) An experiment as in Fig. 2 was performed for cell-free HIV-1 infection of MT-4 cells with increasing MOI in the presence of indicated single or combined antiretroviral inhibitors. Error bars represent the standard deviation of 3 measurements. (B) Changes in IC90 relative to MOI = 1 were plotted for each viral dose to display the MOI-dependence of NRTIs. (C) Changes in IC90 relative to MOI = 1 were plotted for increasing viral MOI to display the MOI-independence of NNRTIs and inhibitor combinations. (D) Graph displays the correlation between the effectiveness of ART inhibitors and combinations against HIV-1 cell-to-cell transmission and MOI-independence. Specifically, the comparison of the change in IC90 of co-culture over cell-free infection is plotted over the change in IC90 of MOI = 25 over MOI = 1.