Biphasic Euchromatin-to-Heterochromatin Transition on the KSHV Genome Following De Novo Infection
Figure 5
Recruitment of components of the PRC2 and PRC1 complexes onto the KSHV genome during de novo infection.
(A) Time-course ChIP analysis of the binding of EZH2 (PRC2), RING1B and RYBP (PRC1) onto KSHV promoters at 4, 24, and 72 hpi and during latency. (B) Genome-wide recruitment of EZH2 and RING1B to the KSHV genome at 4 and 72 hpi. The Pearson correlation between the binding of EZH2 and RING1B is 0.6 at 72 hpi. Labels are the same as in Figure 3.