The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
Figure 5
Higher levels of somatic hypermutation correlates with greater neutralization breadth and potency.
(A) Summary of neutralization data in Figure 4A–B by each clade neutralized. Listed in colored boxes are percentage values. (B) Overall mutation frequencies of mAb combinations, which were calculated by overall number of nucleotide mutations in both heavy and light chains divided by combined heavy and light chain lengths. The mutation frequency of each heavy and light chain was calculated over both V- and J-genes.