Protein Trafficking through the Endosomal System Prepares Intracellular Parasites for a Home Invasion
Figure 2
Comparative bioinformatics analysis of genes coding components of vesicle-mediated trafficking and endosomal sorting in apicomplexan parasites, Saccharomyces cerevisiae, and Homo sapiens.
Most of these genes and their corresponding accession numbers were collected from Eupathdb.org (for apicomplexan parasites) and uniprot.org (yeast and human cells). The data from apicomplexan parasites Toxoplasma gondii (T. gondii), Plasmodium falciparum (P. falciparum), Theileria parva (T. parva), and Cryptosporidium parvum (C. parvum) were compared with human (H. sapiens) and the yeast Saccharomyces cerevisiae (S. cerevisiae). AP, adaptor protein; GGAs, Golgi-localized, γ-ear–containing, ADP-ribosylation factor binding protein; COPI, Coatomer complex I (retrograde transport from trans-Golgi apparatus to cis-Golgi and endoplasmic reticulum); COPII, Coatomer complex II (anterograde transport from ER to the cis-Golgi); ESCRT, Endosomal Sorting Complex Required for Transport.