Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle
Figure 5
Global sensitivity analysis of the replication model.
Sensitivity analysis was performed using the extended Fourier Amplitude Test (eFAST) at (A) 4 hours and (B) 72 hours. Shown are eFAST total order sensitivity indices for plus strand RNA; sensitivities for minus strand RNA and viral protein can be found in supplementary figure S4. The dotted blue line indicates the level of a negative control parameter that does not occur in any of the equations. Sensitivities lower or equal to this negative control should not be considered significantly different from zero [39].