A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity
Figure 5
Suppression of HSV-2 in infected human ex vivo tonsillar tissue by adefovir and PMEO-DAPym.
Blocks of human tonsillar tissue were inoculated ex vivo with HSV-2 (G) and treated or not with adefovir or PMEO-DAPym. We monitored HSV-2 (G) replication by measuring viral DNA in culture media at different times throughout the culture period. Presented are means ± SEM of cumulative HSV-2 (G) replication in tissues from two to six donors. For each donor, data represent pooled viral release from 27 tissue blocks.