Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum
Figure 5
Role of mevalonate pathway for extracellular siderophores in A. fumigatus corneal infection.
A. Mevalonate extracellular siderophore biosynthesis pathway. B–E. C57BL/6 mice infected intrastromally with A. fumigatus ΔsidH and ΔsidI mutant strains. B. CFU per eye at 4 h and 48 h post-infection. C. Representative eyes showing corneal opacity D. Quantification of percent corneal opacity and E. total corneal opacity. B, D, E: Data points represent individual corneas. All panels show representative data from one experiment except for panel B which shows pooled data from repeat experiments. Similar results were found in 3 repeat experiments. Abbreviations: HMG-CoA: 3-hydroxy-3-methyl-glutaryl-CoA.