Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy
Figure 9
High levels of IDO1 in high EBV positive gastric carcinomas.
(A) Gene expression profile of the cohort of 32 gastric carcinoma samples (12 EBV-positive and 20 EBV-negative). Both total EBV reads and IDO1 expression (RPKM-reads per kilobase of exon model per million mapped reads) are represented as red and blue columns, respectively. (B) Gene expression profile of the cohort of 21 Vietnamese gastric carcinomas and 5 normal adjacent samples. Both relative RPMS1 expression (-fold) and relative IDO1 expression (-fold) are represented as red and blue columns and are the fold difference compared to the average of normal adjacent control values. (C) Images of paraffin-embedded human gastric carcinoma probed for EBER using in situ hybridization or IDO1 staining with immunohistochemistry. F8 and A15 each represent a specific gastric carcinoma on the tissue array selected to be closely matched with respect to age, tumor grade and stage. Scale bar represents 50 µm.