Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice
Figure 5
The PRRs TLR2, NOD2, and FPR1 contribute to optimal production of IL-1β during infection.
TLR2−/−, NOD2−/−, FPR1−/− and wt mice were inoculated intradermally with S. aureus. (A) Mean total lesion size (cm2) ± SEM. (B) In vivo bioluminescence quantified by mean total flux (photons/s) ± SEM (logarithmic scale). (C) Mean IL-1β protein levels (pg/mg tissue weight) ± SEM from lesional skin at 4 hrs after inoculation. (D) Mean myeloperoxidase (MPO) activity (U/mg tissue weight) ± SEM from lesional skin at 4 hrs after inoculation. *p<0.05, †p<0.01, TLR2−/−, NOD2−/− or FPR1−/− mice versus wt mice (Student's t-test). Data are from 2 experiments with at least 4 mice/group per experiment.