The Genome of the Obligate Intracellular Parasite Trachipleistophora hominis: New Insights into Microsporidian Genome Dynamics and Reductive Evolution
Figure 2
Putative regulatory motifs in the intergenic regions of T. hominis.
The intergenic regions upstream of T. hominis protein coding genes are enriched for both the canonical yeast-type TATA box (A, B) and a microsporidia-specific “CCC” motif (C, D). (E) The longer scaffolds of the T. hominis assembly also enabled us to robustly identify additional enriched motifs upstream from coding sequences (Figure S3, Table S4, S5). These included sequences with significant similarity to binding sites for Lim1-like homeobox-binding and fork head-containing transcription factors, as well as the cell cycle regulator Cdc5. The q-value for a match between a motif identified in T. hominis and the database consensus motif is a p-value that has been corrected for multiple testing by the False Discovery Rate method.