DNA Mutations Mediate Microevolution between Host-Adapted Forms of the Pathogenic Fungus Cryptococcus neoformans
Figure 5
Multiple mechanisms revert mutations in RAM pathway genes to wild type morphology.
Mutant strains were plated on FK506 to select for revertants. Regions surrounding the mutations were amplified and sequenced. A. Reversion of the stop codon in tao3 mutant F7. B. Reversion of a 16 bp tandem duplication in SOG2. The duplicated region is colored blue. Changes between strains that are responsible for the mutation or reversion back to wild type are colored red.