Slc15a4, a Gene Required for pDC Sensing of TLR Ligands, Is Required to Control Persistent Viral Infection
Figure 5
Prophylactic treatment with CpG-DOTAP prevents persistent viral infection.
WT mice were treated with vehicle or i.v. 2 µg CpG-ODN in DOTAP (“Rx”) either 4 h prior, 4 h post or 3 days post infection with LCMV Cl13. Serum was collected at the indicated times post infection and titered for infectious virus. CpG-DOTAP: CpG-A plus DOTAP (Roche); l.o.d., limit of detection. Mean and standard error of the mean are shown for 5 mice per group of infected mice. 1 of 2 similar experiments is shown. Unless marked, p>0.05 between treatment groups and not statistically significantly different.