Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis
Figure 2
Lack of Ccr1 improves survival without affecting tissue fungal burden in a mouse model of invasive candidiasis.
(A) Ccr1−/− mice have 3-fold better survival compared to Ccr1+/+ mice. P = 0.0008. Data are from three independent experiments with a total of thirty-two Ccr1+/+ and thirty-three Ccr1−/− mice. (B) Ccr1−/− mice develop less severe weight loss compared to Ccr1+/+ mice after Candida infection. *P<0.05. Data are from three independent experiments using twenty-four Ccr1+/+ and twenty-one Ccr1−/− mice. (C–F) Ccr1 deficiency does not affect tissue fungal burden in kidney (C), spleen (D), liver (E) or brain (F). Data are from four independent experiments using twenty-four Ccr1+/+ and twenty-one Ccr1−/− mice. Inoculum, 1.25×105 CFU.