IL-10-Producing Th1 Cells and Disease Progression Are Regulated by Distinct CD11c+ Cell Populations during Visceral Leishmaniasis
Figure 2
Costimulatory molecule expression on cDCs during chronic infection.
(A) Splenic cDCs were gated as MHCIIhiCD11chi cells (top panel) and further gated into the three major subsets based on CD4 and CD8α expression (bottom panel). (B) Surface expression of CD40, CD80, CD86 and PD-L1 on the entire cDC population. (C–F) Surface expression of CD40 (C), CD80 (D), CD86 (E) and PD-L1 (F) by each cDC subset. Data are expressed as mean fold change ± SEM of the MFI on cDCs from infected mice compared to naïve mice (n = 4 mice per group). Data is representative of 3 experiments.