The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection
Figure 5
Lectin pathway deficiency significantly increases the severity of S. pneumoniae infection.
Lectin pathway deficient mice (open squares) and WT littermates (crosses) were infected intranasally with 1×106 cfu S. pneumoniae D39. C57/BL6 Masp2−/− (A) and C57/BL6 Fcna−/− (B) mice are impaired in their survival of S. pneumoniae infection (Mantel-cox log-rank test). C–F. Viable S. pneumoniae counted in lung homogenates and peripheral blood at the indicated time points after infection. Results in C–E are means (±SEM) of five animals sacrificed at each time point. *p<0.05; **p<0.01 (ANOVA).