Dengue Virus Infection Perturbs Lipid Homeostasis in Infected Mosquito Cells
Figure 5
Several lipid classes are differentially regulated in replication complex membranes isolated from DENV infected cells.
Panel A shows fold changes for each lipid class significantly (p<0.05) regulated in membrane fractions isolated from DENV infected (red) or UV-DENV exposed (blue) cells compared to the mock control. Infection was carried out using an MOI of 20. Panels B–D show fold changes for individual molecular species within each lipid class that are regulated. PC, phosphatidylcholine; PE, phosphatidylethanolamine; PG, phosphatidylglycerol; MG, monoacylglycerol; DG, diacylglycerol; PA, phosphatidic acid. See supplementary table S2 for a complete list of lipid features detected in this analysis and supplementary figure 1 for a heat map representation of the data. Three replicates were included in the lipidomic analyses.