Portrait of Candida albicans Adherence Regulators
Figure 6
Portrait of C. albicans adherence regulators.
Our main findings are summarized with transcription factors (blue boxes) connected to cell surface genes (green boxes) and the target process of adherence. Bcr1 promotes adherence through stimulation of ALS1 expression. Snf5 promotes adherence through stimulation of ACE2 expression. Try2, Try3, Try4, Try5, Suc1, Fgr27, Zcf28, and Uga33 are required for adherence and required for the expression of CSTAR genes. CSTAR gene products include numerous predicted cell wall proteins; we hypothesize that many CSTAR gene products mediate adherence. Zap1 is also a positive regulator of CSTAR genes, but it is not required for adherence in our assays. Ada2, Met4, and Try6 are negative regulators of many CSTAR genes. Finally, many transcription factors are required for adherence (Arg81, Cas5, Czf1, Crz2, Dal81, Fcr3, Leu3, Not3, Taf14, War1, Znc1, Zfu2, Zcf8, Zcf31, Zcf34, Zcf39), and govern expression of one or several classes of genes (summarized in Figure 2B), but cannot be connected to specific functional targets.