Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus
Figure 5
Histological analysis of peripheral organs from Andes virus infected hamsters.
Representative samples of heart, kidney, liver, lymph nodes and spleen sections collected at day 12 post-infection from a terminally ill, ANDV infected hamster are shown (H&E 200X, anti-Andes virus nucleoprotein IHC 400X). Extensive viral antigen was noted in endothelial cells of all tissues analyzed (black arrow), including endocardial endothelium in heart sections (open arrow) and glomerular tuft endothelium in kidney sections (circled areas) as well as hepatocytes and Kupffer cells in liver sections (denoted with an H and K, respectively) and dendritic cells and macrophages in lymph nodes (circled area). Despite the high frequency of antigen positivity in peripheral tissue samples, histological abnormalities were infrequent and largely unremarkable in these organs.