The Role of Sialyl Glycan Recognition in Host Tissue Tropism of the Avian Parasite Eimeria tenella
Figure 6
Three-dimensional structure of the MAR1b domain from EtMIC3.
(a) Superposition of EtMIC3-MAR1b (red; PDB code 2LBO) on the MAR2 domain from TgMIC1 (PDB code 2JH1; cyan) showing the position of the disulfide bonds and ‘MAR1 insertion’ [4], [5]. Left and right images represent views from two orientations (Figure S1 and S4). (b) Superposition of EtMIC3-MAR1b (red; PDB code 2LBO) on the MAR2 domain from TgMIC1 (PDB code 2JH1; cyan) in complex with Siaα2–3Gal. For clarity only the sialic acid units are shown for both structures. Additional side-chain contacts from the MAR1 domain are shown in red. Conserved binding site HxT side chains are shown in purple. Left and right images represent views from two orientations (Figure S4).