Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1
Figure 6
Similarities in the interactions between adhesion molecules with Ig-like fold and viral receptor-binding proteins.
The Ig-like domains of the receptors are shown in similar orientation and colored in red with the region that appears most structurally variable in cyan. A. Nectin-1 V-domain bound to HSV gD (gold). B. Coxsackie and Adenovirus receptor, CAR, domain D1 bound to Ad12 of adenovirus (blue) (pdb-id 1KAC). C. Junctional adhesin molecule-A, JAM-A, domain D1 bound to reovirus σ1 (green) (pdb-id 3EOY). D. Signaling lymphocyte activation molecule, SLAM, bound to measles virus hemagglutinin, MV-H, (purple) (pdb-id 3ALX).