Structure of Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor Nectin-1
Figure 2
The gD/Nectin-1 and Nectin-1/Nectin-1 interfaces.
A. Representation of the gD/Nectin-1 interface with key contact residues labeled and displayed in stick representation. Nectin-1 and gD are colored as in Fig. 1. B. Surface representation of gD showing the interface with nectin-1. gD is colored as in Fig. 1 with the nectin-1 contact area represented in blue and magenta. Mutations of residues colored blue have been shown to affect nectin-1 binding. Involvement of residues colored magenta has not previously been proposed. Most of the contacts involve residues from the gD C-terminal extension and, Y38 and Q27 from the N-terminal extension. C. Representation of a portion of the nectin-1 dimer interface (pdb-id 3ALP). Residues involved in key dimer interactions and that are involved in the gD/Nectin-1 interface are shown in stick representation. One monomer of nectin-1 is colored orange with black labels and the other is in pink with gray labels. D. Surface representation of the nectin-1 V-domain highlighting residues involved in either gD binding (magenta, left panel) or nectin-1 dimerization (orange, right panel).