Absence of Cross-Presenting Cells in the Salivary Gland and Viral Immune Evasion Confine Cytomegalovirus Immune Control to Effector CD4 T Cells
Figure 5
MHC class I and II expression is absent in intact MCMV infected cells and may be re-expressed at low levels on infected cells in proximity to leukocyte infiltrates.
Three weeks post MCMV-GFP infection, SG sections isolated from B6 mice were stained for MHC class I (A to C; blue) or MHC class II (D and E; blue) as well as with phalloidin (A to E; red), visualizing actin. MCMV-infected cells which are situated distal (A and D) or in proximity (B and E) to cell infiltrates were analyzed. Expression of MHC class I on uninfected AGECs is shown in C. Arrows point out weak MHC class I or MHC class II expression on AGECs. Confocal images were taken with 100 times magnification. Scale bar indicates 10 µm. One representative picture of a minimum of 10 is shown.