Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein
Figure 3
Microarray analysis of gene expression in the lungs of mice on day 2 pi.
(A) Venn diagram showing the distribution of differentially regulated genes during infection with wt or ΔF2 IAV relative to mock-infected mice. (B) Functional categories comparison of differentially expressed genes in lungs of mice infected with wt or ΔF2 IAV. (C) Heat map of selected genes related to innate defense in the lungs of wt- and ΔF2-infected mice at day 2 pi based on analysis using Genespring software (Agilent). Genes shown in red are up-regulated and those shown in blue are down-regulated in infected mice compared to mock-infected mice. Data are expressed in Log base 2 ratio.