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Histo-Blood Group Antigens Act as Attachment Factors of Rabbit Hemorrhagic Disease Virus Infection in a Virus Strain-Dependent Manner

Figure 8

Enzymatic removal of A, B and H from three different rabbit duodenums.

The H epitope was cleaved from an A−B− rabbit duodenum and G1–G6 binding was tested against H removal and a mock treated control (A). A and H were cleaved from an A+B− rabbit duodenum and RHDV binding was tested against A removal, A followed by H removal and a mock treated control (B). A, B and H were removed from an A+B+ rabbit duodenum where A removal, A and H removal, B removal, B and H removal and a mock treated control were tested for G1–G6 binding (C). Control of the enzymatic removal of A, B and H are shown (D).

Figure 8

doi: https://doi.org/10.1371/journal.ppat.1002188.g008