Selection of Resistant Bacteria at Very Low Antibiotic Concentrations
Figure 3
Competition experiments between susceptible and resistant strains, ciprofloxacin.
Competition experiments at different concentrations of ciprofloxacin (A (gyrA2 (D87N)), C (gyrA1 (S83L)), E (ΔacrR) and G (ΔmarR)) and calculated selection coefficients as a function of antibiotic concentrations (B, D, F and H). Fig. A, C, E and G are each based on one single competition experiment (averages of three competitions), while fig. B, D, F and H are calculated from the selection coefficients of 6 competitions (Table S3 in Text S1). Standard errors of the mean are indicated.