Crystallography of a Lewis-Binding Norovirus, Elucidation of Strain-Specificity to the Polymorphic Human Histo-Blood Group Antigens
Figure 8
HBGA-binding outcomes of various mutant P particles with single amino acid mutations in the HBGA-binding interface of VA207.
Binding of wild type (A) and mutant P particles (B to G) to a panel of synthetic oligosaccharides representing HBGAs of H1, H2, H3, A, B, Lea, Leb, Lex, Ley, 3′sLea, and 3′sLex (X-axes). Y axes indicate the optical densities at 450 nm (OD450) that were the average values of quintuplicate (A) and triplicate (B to G) experiments, respectively. Concentrations of the P particles were 10 µg/ml.