Crystallography of a Lewis-Binding Norovirus, Elucidation of Strain-Specificity to the Polymorphic Human Histo-Blood Group Antigens
Figure 6
Extensive interaction network between VA207 P dimer and 3′ sialyl-Lewis X tetrasaccharide.
(A) Stereo view of the binding cavity of VA207 P dimer and the bound 3′ sialyl-Lewis X tetrasaccharide. Protein structure is in ribbon representation, while tetrasaccharide and major amino acid residues involved in interaction are in stick style. Hydrogen bonds are indicated by blue dotted lines; carbon, oxygen and nitrogen atoms are in grey, red and blue, respectively. The two P protomers are in cyan and purple and residues involved in saccharide interactions are labeled. (B) Schematic diagram of P protein and 3′ sialyl-Lewis X tetrasaccharide interaction. Residues of P protein involved in the interaction are labeled with detailed atomic information. Hydrogen bonds were shown as dashed lines with indication of H-bond lengths.