Crystallography of a Lewis-Binding Norovirus, Elucidation of Strain-Specificity to the Polymorphic Human Histo-Blood Group Antigens
Figure 5
Extensive interaction network between VA207 P dimer and Lewis Y tetrasaccharide.
(A) Stereo view of the binding cavity of VA207 P dimer and the bound Lewis Y tetrasaccharide. Protein structure is in ribbon representation as in Figure 3, while tetrasaccharide and major amino acid residues involved in interaction are in stick style. Hydrogen bonds are indicated by blue dotted lines; carbon, oxygen and nitrogen atoms are in grey, red and blue, respectively. The two P protomers are colored in cyan and purple and residues involved in saccharide interactions are labeled. (B) Schematic diagram showing P protein and Lewis Y tetrasaccharide interaction. Residues of P protein involved in saccharide binding are labeled with detailed atomic information. Hydrogen bonds are shown as dashed lines with indication of H-bond lengths.