The Trypanosoma cruzi Protease Cruzain Mediates Immune Evasion
Figure 8
No significant IL12 expression was detected in macrophages infected with wild type T. cruzi while cells treated with 10 µM K11777 had significantly higher cytoplasmic IL12 levels. Increased IL12 expression also occurred in macrophages infected with cruzain-deficient T. cruzi. Results are representative of three independent experiments. A. Wild type-infected control. B. Macrophage infected wild type T. cruzi and treated with 10 µM K11777. C. Macrophage infected with cruzain-deficient T. cruzi.