Rotavirus Stimulates Release of Serotonin (5-HT) from Human Enterochromaffin Cells and Activates Brain Structures Involved in Nausea and Vomiting
Figure 6
Co-localization of rotavirus and 5-HT in EC tumor cells.
(A) Haematoxylin-stained jejunum of RV-infected mice. The picture shows extensive vacuoles characteristic of RV-infected enterocytes at 48 h p.i. (B) Sections of infected intestinal tissue were processed for immunohistochemistry for detection of EC cells with chromogranin A-specific antibodies. Stars indicate EC cells and the arrow identifies a vacuole in the close vicinity of an EC cell in the ileum. (C, D) Sections of jejunum intestinal tissue were stained for RV (red) and 5-HT (green). Arrows indicate EC cells with co-localization (yellow) of the virus and 5-HT.