The Binding of Triclosan to SmeT, the Repressor of the Multidrug Efflux Pump SmeDEF, Induces Antibiotic Resistance in Stenotrophomonas maltophilia
Figure 9
Comparison between the SmeT-Triclosan (in grey) and the QacR-DNA complex (in blue) structures.
Chain A of the SmeT-Triclosan complex structure was superposed with QacR in the QacR-DNA complex structure (PDB entry 1JT0 [64]). The recognition helices α1 and α2 of this chain are placed in the same position than the corresponding helices of QacR (left side in panel A, right side in panel B). On the contrary, helix α1 in chain B is rotated, and helices α2 and α3 are displaced clashing against the DNA (right side in panel A, left side in panel B). This conformation prevents the repressor from binding to DNA. The views shown in panels A and B are obtained by a 180 degrees rotation perpendicular to the DNA axis.