A Role for the Chemokine RANTES in Regulating CD8 T Cell Responses during Chronic Viral Infection
Figure 5
The primary CD8 T cell cytokine response is diminished in the absence of RANTES at one week after clone 13 infection.
WT and RANTES−/− mice were infected with LCMV clone 13 and T cell responses examined eight days later. The total number of LCMV-specific CD8 and CD4 T cells was measured by tetramer staining as well as peptide stimulation and ICS to detect cytokine production. Expression of IFNγ, TNFα and MIP1α was examined (A–D). Graphs show total numbers per spleen. Representative plots of IFNγ, TNFα and MIP-1α expression (D). Data are representative of 3 independent experiments with five mice per group.