Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt
Figure 5
Effect of HA mutations in sublineage BII viruses on receptor specificity of EG/D1 HA.
The mutations found in sublineage BΙΙ viral HAs were introduced as single and multiple mutations into the HA of EG/D1 virus. Direct binding to sialylglycopolymers containing either α2,3-linked (blue) or α2,6-linked (red) sialic acid was measured. Mutations are indicated by subscripts. Each data point is the mean ± SD of triplicate experiments.