Transition of Plasmodium Sporozoites into Liver Stage-Like Forms Is Regulated by the RNA Binding Protein Pumilio
Figure 2
puf2- parasites transform into early liver stage EEF's in mosquito salivary glands.
A, maximum projection of a z-series scan of infected mosquito salivary glands on day 30 of mosquito infection. B, Development of salivary gland-resident parasites from day 18 to day 30 after mosquito infection; puf2- undergo exo-erythrocytic liver stage metamorphosis with bulging visible at day 22 and complete transformation at day 30. C, Proportion of sporozoites versus EEF-like's of wild type, puf1- and puf2- parasites in mosquito SG's during 13 days of salivary gland infection. Scale bars = 10 µm.