Compensatory Evolution of pbp Mutations Restores the Fitness Cost Imposed by β-Lactam Resistance in Streptococcus pneumoniae
Figure 1
Correlation plot between the fitness value of pbp mutants, obtained by using pbp genes from Cba-19 and Cba-28 clinical strains, and the penicillin MIC increase found (µg/ml).
A) Correlation for Cp1015 pbp19 mutants, Cp1015 pbp2b19 (diamonds), Cp1015 pbp2b19 pbp2x19 (triangles), and Cp1015 pbp2b19 pbp1a19 pbp2x19 (circles). B) Correlation for Cp1015 pbp28 mutants, Cp1015 pbp2b28 (diamonds), Cp1015 pbp2b28pbp2x28 (triangles), and Cp1015 pbp2b28 pbp2x28 pbp1a28 (circles).