Early Target Cells of Measles Virus after Aerosol Infection of Non-Human Primates
Figure 5
Dissemination of MV into the lymphoid organs via blood vessels.
(A, B) H&E staining (left panel) and EGFP staining (right panel) on serial sections of tonsils at 4 d.p.i. (A) and 5 d.p.i. (B). Asterisk denote the proximity of venules to MV-infected cells. (C) Dual labeling of EGFP (green) and the endothelial marker CD31 (red) performed on the tonsils from animals euthanized 5 d.p.i. The left panel shows MV-infected cells in close proximity to CD31+ endothelial cells of venules (arrows), the right panel shows an MV-infected cell migrating through the wall of the venule (arrow). DAPI was used to counter stain nuclei in blue. Single color images for (C) are available as supporting data (figure S2).