Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens
Figure 5
Comparison of CD46-4D with the structure of the N-terminal four repeats of FH.
The structures of CD46-4D (red) and FH (PDB code 2WII, blue) [42] were superimposed based on residues in SCR3 only. This yielded an r.m.s. deviation of 1.43 Å for 60 pairs of residues. Shown in grey is the C3b ligand that was crystallized in complex with FH. The individual SCR domains of CD46-4D and FH are labeled in red and blue, respectively.