PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90
Figure 5
Swi4 and Cch1-Mid1 play critical roles in ergosterol biosynthesis inhibitor tolerance of C. albicans.
Deletion of SWI4 or components of the Cch1-Mid1 channel confer increased sensitivity to the ergosterol biosynthesis inhibitors in a MIC assay. Deletion of Rlm1 had no impact on drug sensitivity. A strain lacking the catalytic subunit of calcineurin (Cna1) is included for reference. Data was analyzed after 48 hours in YPD at 35°C as in Figure 1A. The minimum drug concentration that inhibits growth by 80% relative to the drug-free growth control (MIC80) is indicated for each strain.